Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor
نویسندگان
چکیده
منابع مشابه
GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils.
We examined GH and GH receptor expression in human leukemic cell lines and leukocytes of normal subjects to elucidate the cell types expressing GH and GH receptor, the individual variations of their expressions, their correlation and the relationships with serum IgG and IGF-I concentrations. In addition, the expression of GH secretagogue receptor, which enhances GH secretion from the anterior p...
متن کاملNovel ghrelin analogs with improved affinity for the GH secretagogue receptor stimulate GH and prolactin release from human pituitary cells.
OBJECTIVE Ghrelin, a recently identified 28-amino acid peptide is a potent GH secretagogue (GHS) produced predominantly by the stomach. Ghrelin stimulates GH secretion through binding to the GHS receptor in the hypothalamus and pituitary. In addition to the GH-releasing action, ghrelin has been found to be a powerful orexigenic factor. To assess the direct in vitro effects of ghrelin on human p...
متن کاملRegulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor.
GH secretagogues are an expanding class of synthetic peptide and nonpeptide molecules that stimulate the pituitary gland to secrete GH through their own specific receptor, the GH-secretagogue receptor. The cloning of the receptor for these nonclassical GH releasing molecules, together with the more recent characterization of an endogenous ligand, named ghrelin, have unambiguously demonstrated t...
متن کاملGhrelin -- a new endogenous growth hormone secretagogue.
Ghrelin is a new endogenous peptide, discovered in 1999 by Kojima et al., as the result of a search for an endogenous ligand for an orphan receptor of known structure and function. Ghrelin is composed of 28 amino acids and is produced mostly by cells of the stomach, hypothalamus, and hypophysis, but it has also been detected in other tissues. Its discovery is related to the development of a new...
متن کاملGhrelin: what do we know about its role in health and disease?
Ghrelin is a 28 amino acid peptide predominantly produced by the stomach that has been discovered to be a natural ligand of the orphan growth hormone (GH) secretagogue (GHS) receptor (GHS-R) type 1a. Like synthetic GHS, ghrelin possesses a strong GH-releasing effect provided that the molecule is acylated in serine3 and it is thought to be a natural GHS of major importance in the control of soma...
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2005
ISSN: 0300-0664,1365-2265
DOI: 10.1111/j.1365-2265.2004.02160.x